PRP GENOTYPES AND EXPERIMENTAL SCRAPIE IN ORALLY INOCULATED SUFFOLK SHEEP IN THE UNITED-STATES

Authors
OROURKE KI HOLYOAK GR CLARK WW MICKELSON JR WANG S MELCO RP BESSER TE FOOTE WC
Citation
Ki. Orourke et al., PRP GENOTYPES AND EXPERIMENTAL SCRAPIE IN ORALLY INOCULATED SUFFOLK SHEEP IN THE UNITED-STATES, Journal of General Virology, 78, 1997, pp. 975-978
Citations number
43
Categorie Soggetti
Virology,"Biothechnology & Applied Migrobiology
Journal title
Journal of General Virology → ACNP
ISSN journal
00221317
Volume
78
Year of publication
1997
Part
4
Pages
975 - 978
Database
ISI
SICI code
0022-1317(1997)78:<975:PGAESI>2.0.ZU;2-2
Abstract
One-hundred and three United States Suffolk sheep were inoculated oral ly with a scrapie agent preparation and monitored for clinical disease and histopathological lesions characteristic of scrapie. A retrospect ive study of the polymorphisms at codon 171 of the prion protein (PrP) gene was performed on these sheep. All 63 sheep that developed scrapi e during the observation period were homozygous for the glutamine 171 (171-QQ) PrP allele. Twelve 171-QQ sheep failed to develop disease. Al l 5 sheep homozygous for arginine (171-RR) and all 23 heterozygous (17 1-QR) sheep remained free of scrapie.