THE PROGESTERONE METABOLITE 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE REDUCESK-INDUCED GABA AND GLUTAMATE RELEASE FROM IDENTIFIED NERVE-TERMINALS IN RAT HIPPOCAMPUS - A SEMIQUANTITATIVE IMMUNOCYTOCHEMICAL STUDY()

Authors
TAUBOLL E OTTERSEN OP GJERSTAD L
Citation
E. Tauboll et al., THE PROGESTERONE METABOLITE 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE REDUCESK-INDUCED GABA AND GLUTAMATE RELEASE FROM IDENTIFIED NERVE-TERMINALS IN RAT HIPPOCAMPUS - A SEMIQUANTITATIVE IMMUNOCYTOCHEMICAL STUDY(), Brain research, 623(2), 1993, pp. 329-333
Citations number
24
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
623
Issue
2
Year of publication
1993
Pages
329 - 333
Database
ISI
SICI code
0006-8993(1993)623:2<329:TPM5R>2.0.ZU;2-2
Abstract
5Alpha-pregnan-3alpha1-20-one (3alpha-OH-DHP) reduced the depolarizati on-induced loss of GABA and, to a lesser extent, the glutamate-like im munoreactivities from nerve terminals in the in vitro hippocampal slic e. Phenobarbital (PB) had similar effects. These results suggest that 3alpha-OH-DHP affects presynaptic transmitter release, possibly in a b arbiturate-like manner.