W. Raffoul et al., EXPERIMENTAL AND CLINICAL-STUDIES ON THE ABSORPTION AND TOXICITY OF CERIUM NITRATE, European journal of plastic surgery, 16(4-5), 1993, pp. 180-185
In this publication we present the results of three studies concerning
the toxicity and absorption of cerium. In the first experimental stud
y in rats, following the application of a 2.2% solution of cerium nitr
ate on dorsal wounds for five weeks, delayed healing was demonstrated
and histological examination revealed richly vascularized granulation
tissue in which microcalcifications and foreign-body type giant cells
were found. A high concentration of cerium was found in the liver. The
second experimental study employing rat enterocytes demonstrated an i
mmediate cellular toxicity after exposure to a 2.2% cerium nitrate sol
ution. Correction of pH and/or osmolarity did not play a protective ro
le. In the clinical evaluation, significant levels of cerium were foun
d in six blood samples and four urinary specimens, following the appli
cation of a 2.2% cerium nitrate solution on burn wounds. Liver biopsie
s were performed in two cases. There were no abnormal histological fin
dings, but cerium levels were elevated.