A brief mental fatigue questionnaire was administered to normal subjec
ts and muscle-diseased, Chronic Fatigue Syndrome (CFS), recovered CFS
and depressed patients. The questionnaire was found to have excellent
internal consistency and discriminated effectively between CFS and dep
ressed patients on the one hand and recovered CFS, normal and muscle-d
iseased patients on the other. However, the scale failed to discrimina
te between CFS and depressed subjects, who were found to experience qu
alitatively and quantitatively similar mental fatigue symptoms.