THE PHARMACOKINETICS OF SURICLONE AFTER SINGLE-DOSE AND MULTIPLE-DOSEADMINISTRATION IN HEALTHY ELDERLY VOLUNTEERS

Healthy elderly people aged 70 or more should receive a starting dosag e of the anxiolytic drug suriclone half that recommended for younger p eople; frail or ill elderly people may require further dosage reductio n. These conclusions were based on a study of the pharmacokinetics and tolerability of orally administered suriclone after a single dose of 0.2mg and after multiple doses of 0.2mg 3-times daily in 8 male and 8 female healthy elderly volunteers. Informal comparison of the pharmaco kinetic data from this study with studies in younger volunteers showed a 53% decrease in clearance and an 84% increase in elimination half-l ife. Area under the plasma concentration-time curve (AUC) for suriclon e and total antigenic products in the elderly were twice the values in younger volunteers when adjusted for different dosage. There were no significant changes in pulse rate or blood pressure during the study. One person showed a change from sinus rhythm to atrial fibrillation. S ix people had transient adverse events including unsteadiness, vomitin g, difficulty in reaching for objects, urinary incontinence and sedati on.