CONTINUOUS HORMONE REPLACEMENT THERAPY WITH ESTRADIOL VALERATE AND CHLORMADINONE ACETATE IN ADJUSTABLE DOSAGES - A PRELIMINARY-STUDY

A group of 62 peri- and postmenopausal women suffering from vasomotor disturbances and a variety of other symptoms were treated with estradi ol valerate and chlormadinone acetate continuously using an adjustable dosage regimen. They obtained complete relief from vasomotor symptoms . The continuation rate was 81% after 1 year. In 18 patients the dose had to be adjusted because of breakthrough bleeding (n = 12), mastodyn ia (n = 3), and for the prevention of bone loss. In 11/12 patients bre akhrough bleeding could be stopped by adjusting the dosage. This regim en seems to offer a more flexible approach to hormone replacement ther apy (HRT) in the postmenopause than presently available combined prepa rations for continuous use.