We investigated interaction of the human bilateral hand motor area usi
ng two magnetic stimulators. A conditioning shock over the motor corte
x facilitated the response evoked in the ipsilateral first dorsal inte
rosseous muscle by a test shock over the contralateral motor cortex gi
ven under the limiting conditions of a small conditioning shock over a
very small area and a small test shock. This effect was so weak that
it was not elicited under slightly different conditions. We conclude t
hat an excitatory, but weak, connection between strictly homotopic are
as of the bilateral hand motor cortices exists in humans.