PULSATILE VERSUS NONPULSATILE REPERFUSION IMPROVES CEREBRAL BLOOD-FLOW AFTER CARDIAC-ARREST

Cardiopulmonary bypass using nonpulsatile flow (NF) is currently advoc ated for treating refractory cardiac arrest. Although the heart can be revived using cardiopulmonary bypass support, the brain must recover if such therapy is to be considered successful. Previous studies have demonstrated that pulsatile flow (PF) reperfusion can improve neurolog ic outcome compared with NF reperfusion after cardiac arrest. The purp ose of this study was to assess cerebral perfusion and oxygen consumpt ion during either PF or NF reperfusion after cardiac arrest. Dogs (n = 22) underwent a 15-minute cardiac arrest followed by 1 hour of either PF or NF reperfusion. Microsphere techniques were used to assess cere bral perfusion and oxygen consumption at 3, 15, and 60 minutes of repe rfusion. Mean arteriovenous gradients and total brain flows were simil ar in both groups. However, cerebral oxygen consumption was significan tly improved at 3 minutes of reperfusion with PF versus NF (1.8 +/- 0. 3 versus 0.9 +/- 0.3 mL O2 . dL-1 - min-1, respectively; p < 0.05). Th ese results were coincident with improved gray-to-white flow ratios at 3 minutes of PF versus NF reperfusion (5.2 +/- 1.0 versus 2.0 +/- 0.3 , respectively; p < 0.05). There were no statistically significant dif ferences ir, brain perfusion variables by 15 minutes of reperfusion. H owever, a relative hyperemia was exhibited at 15 minutes of NF versus PF reperfusion, which suggests nutrient flow was insufficient during e arly NF versus PF reperfusion. In conclusion, PF reperfusion can bette r restore cerebral blood flow and oxygen consumption than can NF reper fusion. These findings provide a mechanism that explains how PF versus NF reperfusion may have improved neurologic outcome after cardiac arr est in previous studies.