EFFECTS OF HYPERTONIC SALINE SOLUTION (20-PERCENT) ON CARDIODYNAMICS DURING HEMORRHAGIC-SHOCK

The cardiodynamic effects of using hypertonic saline solution were ana lyzed in dogs after inducing hemorrhagic shock. Administration of 1.5 mL/kg 20% sodium chloride resulted in circulatory improvement: 200% in crease in blood pressure, 260% increase in cardiac output, 60-70% incr ease in pulmonary arterial pressure, 66% increase in pulmonary wedge p ressure, 200% increase in central venous pressure, 33% decrease in tot al peripheral resistance, and 40% decrease in pulmonary vascular resis tance. The effects of sodium chloride on cardiodynamics probably resul ted in elevation of preload and reduction of afterload. (C) 1993 Wiley -Liss, Inc.