The formation of cryoproteins is rare and as a rule provocated by seve
ral diseases so as infections. This process is stimulated by cooling w
hich is not pathogenic. This increase of immune proteins is localized
in B-lymphocytes and is mainly a humoral reaction, mediated by antibod
ies of the type of immunocomplexes. Simultaneous an IgE-mediated type
I-reaction (anaphylaxia) is possible (10%). In this case the clinical
pictures are a urticaria reproducible by cold, erectile tissues are ra
rely. An etiopathogenetic meaning of the Hepatitis-B-Virus is showing
off. The clinical symptoms, laboratory, and histopathological data of
a female patient with the detection of cryoglobulinemia who is suffere
d from a bronchopneumonia is demonstrated. Clinical manifestations of
the organs so as therapeutical possibilities are in detail described.