Jc. Laiuppa et Dm. Lemaster, SYNTHESIS OF D,L-[2-N-15,5-C-13]GLUTAMIC ACID, Journal of labelled compounds & radiopharmaceuticals, 33(10), 1993, pp. 913-919
A one-pot procedure is described for the synthesis of D,L-[2-N-15,5-C-
13]glutamic acid from 2-bromo-4-butyrolactone utilizing potassium N-15
-phthalimide and potassium C-13-cyanide as label sources. Following a
two column purification procedure, the final product is obtained in 38
% yield based on the equimolar label sources.