Mb. Awang et al., RADIOLABELING OF PHARMACEUTICAL DOSAGE FORMS BY NEUTRON-ACTIVATION OFSM-152, Journal of labelled compounds & radiopharmaceuticals, 33(10), 1993, pp. 941-948
Samarium-152 can be activated in a neutron flux for the labelling of p
harmaceutical dosage forms for evaluation by gamma scintigraphy. The s
amarium is incorporated as samarium oxide powder which is available wi
th Sm-152 in its natural isotopic abundance or isotopically enriched.
The yield of Sm-153 was reduced considerably following the neutron act
ivation of the non-isotopically enriched oxide. This can be attributed
to the high neutron capture by Sm-149 present in the non-isotopically
enriched oxide. In order to keep the mass of the added oxide powder t
o the minimum and also to reduce the neutron irradiation time, it is r
ecommended that samarium oxide enriched with Sm-152 should be used rou
tinely when radiolabelling pharmaceutical dosage forms.