Objective. Major pediatric textbooks advocate a chest radiograph as pa
rt of the diagnostic evaluation for a sepsis workup for febrile infant
s less than 3 months old. Very few studies have addressed the value of
performing a chest radiograph in this situation. Two studies previous
ly published lack the numbers to statistically justify a conclusion ab
out the need to perform a chest radiograph in the febrile infant. Meth
ods. Evaluated were 197 febrile infants 3 months old or less with a hi
story, physical examination, chest radiograph, and other laboratory st
udies to determine the cause of their fever. This group of infants was
combined with the group of infants from two similar studies published
previously in the literature using cumulative meta-analysis. The comb
ined group resulted in 617 infants. Results. The combined group of inf
ants had 361 infants who had no clinical evidence of pulmonary disease
on history or physical examination. All 361 infants had normal chest
radiograph. These results gave a 95% confidence interval that the chan
ce of a positive chest radiograph in a patient with no pulmonary sympt
oms would occur less than 1.02% of the time. Conclusions. The generall
y advocated policy of obtaining a chest radiograph as part of the seps
is workup in febrile infants should be discontinued, and chest radiogr
aphs should be obtained only in febrile infants who have clinical indi
cations of pulmonary disease.