DISPOSITION KINETICS, URINARY-EXCRETION AND DOSAGE REGIMEN OF KANAMYCIN IN BUFFALO CALVES FOLLOWING SINGLE INTRAVENOUS ADMINISTRATION

The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dos e of 10 mg/kg body weight. The distribution and elimination half-lives were 0.12 +/- 0.01 h and 1.94 +/- 0.11 h, respectively. The apparent volume of distribution and total body clearance were 0.2 +/- 0.01 L/kg and 92.9 +/- 3.69 ml/kg/h, respectively. About 74% of the administere d dose was excreted in urine in 24 h. A suitable dosage regimen for th e intravenous administration of kanamycin was also calculated.