S. Rampal et al., DISPOSITION KINETICS, URINARY-EXCRETION AND DOSAGE REGIMEN OF KANAMYCIN IN BUFFALO CALVES FOLLOWING SINGLE INTRAVENOUS ADMINISTRATION, Veterinary research communications, 17(3), 1993, pp. 219-225
The disposition kinetics and appropriate dosage regimen for kanamycin
were investigated in buffalo calves following a single intravenous dos
e of 10 mg/kg body weight. The distribution and elimination half-lives
were 0.12 +/- 0.01 h and 1.94 +/- 0.11 h, respectively. The apparent
volume of distribution and total body clearance were 0.2 +/- 0.01 L/kg
and 92.9 +/- 3.69 ml/kg/h, respectively. About 74% of the administere
d dose was excreted in urine in 24 h. A suitable dosage regimen for th
e intravenous administration of kanamycin was also calculated.