B. Unterhalt et al., 7-METHYL-ISOCHROMAN-1-CARBOXYLIC ACID AND 7-METHYL-ISOTHIOCHROMAN-1-CARBOXYLIC ACID AND THEIR DERIVATIVES, Die Pharmazie, 52(3), 1997, pp. 186-189
7-Methyl-isochroman (1) and 7-methyl-isothiochroman (7) are reacted to
the acids 3, 9 and the related esters 5, 10 via their nitriles 2, 8.
Aminoethylation in 1-position gives the compounds 6, 11, and 12. These
were inactive in pharmacological screening.