GENETIC-CONTROL OF LEISHMANIA-MAJOR INFECTION IN CONGENIC, RECOMBINANT INBRED AND F2 POPULATIONS OF MICE

The outcome of subcutaneous infection with L. major NIH 173 was evalua ted in a series of recombinant inbred and congenic strains, as well as F2 progeny generated from a genetic linkage testing stock carrying th e visible markers Ra, Os, and Pt. The disease parameters monitored wer e the incidence of open or necrotic lesions and footpad depths of infe cted feet, and the incidence and number of amastigotes in livers follo wing infection. Regions of mouse chromosomes 2, 4, 7, 8, 12 and 15 wer e excluded from linkage to a gene (Scl-1) involved in the susceptibili ty of inbred strains of mice to cutaneous infection with L. major NIH 173 by F2 and congenic strain analyses. Strain distribution patterns g enerated for Scl-1 in the CXB and CXS recombinant inbred strains sugge sted linkage to the distal end of mouse Chromosome 11.