MODELING SEVERAL TYPES OF SD PROPAGATION TAKING INTO ACCOUNT NONUNIFORM DENSITY OF ACTIVE ELEMENTS IN EXCITABLE MEDIA

Character of spreading depression (SD) wave propagation was studied on two-dimensional model of excitable tissue. It was shown that strips w ith diminished density of active elements were of different permeabili ty for the waves depending on their front orientation and curvature. W hen triggered near the border with a rarefied strip the wave could not penetrate through it and the effect of wave <<sliding>> along this st rip was observed. In several-compartment model imitating the diffusly connected cortico-striatal system of the rat brain the sequence of eve nts was determined by a primary focus position. In this model a single stimulus could provoke not only one wave but re-entry waves and rever berators. Described mechanism of repetitive waves generation in inhomo geneous tissue allow to interpret unusual SD wave consequences observe d in electrophysiological experiments.