RELATIONSHIP BETWEEN FORMULATION, COMPRESSION STRENGTH AND ANTACID ACTIVITY - APPLICATION TO MAGNESIUM CARBONATE-ALUMINUM HYDROXIDE TABLETS

The aim of this work was to study the effect of formulation and compre ssion strength on antacid activity of co-dried magnesium carbonate and aluminium hydroxide tablets, Pharmacotechnical tests have been made o n tablets to determine their principal characteristics. The antacid ac tivity was evaluated in vitro by the modified Holbert-Noble method, It is influenced by compression strength, type of filler and presence of disintegrants. The type of disintegrant does not affect significantly the performance of magnesium-aluminium antacid tablets because their presence accelerates the time to reach the maximum pH-value.