POSTANTIBIOTIC EFFECT OF NORFLOXACIN AND ITS INFLUENCE ON PROFILES OFOUTER-MEMBRANE PROTEINS OF PSEUDOMONAS-AERUGINOSA

Authors
HOSTACKA A KARELOVA E
Citation
A. Hostacka et E. Karelova, POSTANTIBIOTIC EFFECT OF NORFLOXACIN AND ITS INFLUENCE ON PROFILES OFOUTER-MEMBRANE PROTEINS OF PSEUDOMONAS-AERUGINOSA, Die Pharmazie, 52(3), 1997, pp. 238-239
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
52
Issue
3
Year of publication
1997
Pages
238 - 239
Database
ISI
SICI code
0031-7144(1997)52:3<238:PEONAI>2.0.ZU;2-X
Abstract
Norfloxacin at suprainhibitory concentrations induced postantibiotic e ffects (PAEs) in the range of 6 h to 11.4 h (2.MIC) and of 10.1 to mor e than 13.4 h (4.MIC) against three P. aeruginosa strains. After PAEs, the outer membrane profile proteins of the strains studied was change d. Overproduction of 41 kDa protein as well as strong reduction of 23 kDa and 45 kDa proteins were found in all three strains. A reduction o f the protein band in the range of 35 kDa was also observed in all str ains, but to a smaller extent.