M. Weintraub et Bm. Handy, BENZODIAZEPINES AND HIP FRACTURE - THE NEW-YORK-STATE EXPERIENCE, Clinical pharmacology and therapeutics, 54(3), 1993, pp. 252-256
We assessed rates of hip fracture before and after the institution of
the triplicate prescription policy for benzodiazepines in New York Sta
te. All patients 55 years of age or older who had a diagnosis of hip f
racture between January 1, 1986, and June 30, 1991, were considered fo
r the study. Patients with severe trauma, neoplasm, arthritis, or seco
nd admission were excluded. Rates of hip fracture were calculated for
each quarter by age and gender. Benzodiazepine prescribing began to, d
ecline immediately after the triplicate prescription regulation went i
nto effect on January 1, 1989. However, yearly rates of hip fracture f
or women (men) greater-than-or-equal-to 75 years of age per 1000 peopl
e adjusted for New York population changes remained stable at 13.8 (6.
5), 12.6 (5.7), 14.7 (6.7), 14.8 (6.4), 14.4 (6.3), and 14.4 (6.7), fr
om 1986 through the first two quarters of 1991. Regression analyses sh
owed no before or after regulation trend in the rate of hip fracture.
We conclude that no dramatic declines in the rate of hip fractures amo
ng people older than 55 years of age have been observed in association
with the benzodiazepine regulations and decreased benzodiazepine pres
cribing.