3-SUBSTITUTED, IDINYLMETHYL)-1,3-DIHYDRO-1-PHENYL-2H-INDOL-2-ONES AS ACETYLCHOLINE-RELEASE ENHANCERS - SYNTHESIS AND SAR

A series of 3-substituted, idinylmethyl)-1,3-dihydro-1-phenyl-2H-indol -2-ones was synthesized and found to enhance the stimulus-induced rele ase of neurotransmitter acetylcholine (AcCh), and by doing so, might b e useful in treating cognitive disorders where the level of this neuro transmitter may be diminished in the brain, as in Alzheimer's disease. An attempt has been made to correlate the structure of the 3-substitu tion with the ability of the compounds to enhance the release of AcCh from the striatum region of rat brain preparations.