G. Biesenbach et al., LIPID-LOWERING EFFECT OF A NEW FIBER MIXT URE CONSISTING GUAR AND APPLE-PECTIN IN FEMALE TYPE-2-DIABETICS WITH HYPERCHOLESTERINEMIA, Leber, Magen, Darm, 23(5), 1993, pp. 204
The lipid-lowering effect of a new mixture of fiber consisting in guar
and apple-pectin in combination with apple-pomaces has been estimated
in 15 female type 2-diabetics [age xBAR = 62 (52-70) yr] with hyperch
olesterolemia (total-chol >240 mg/dl and LDL-chol >130 mg/dl). After a
dietetic run-in-phase of 3 weeks the patients received the fiber mixt
ure (1 package of 17 g with about 5,9 g watersoluble fiber) dissolved
in 250 ml water for the next 9 weeks: during the first 3 weeks 2 porti
ons per day, the next 3 weeks twice 1/2 portion and the last 3 weeks o
ne 1/2 portion daily. The fiber mixture had to been consumed 30 minute
s before taking a main meal. Regular intake of the fiber product led t
o a significant decrement in blood lipids, and this improvement under
2 portions daily has been maintained for the most part with the reduce
d dosage. The total-chol levels decreased by -11,3% during the first 3
weeks of fiber intake (p<0.05) and by -12,6% during the next 3 weeks
(p<0.05), the decrease during the last 3 weeks under the reduced fiber
intake was -9,6% (ns). The HDL-chol levels remained approximately the
same during the whole period of observation. The triglyceride concent
rations in serum could be lowered by -15,5% during the first 3 weeks o
f fiber intake, and by -19,2% during the next 3 weeks (p<0.05), finall
y the decrease was -12,3% (ns). The atherogenic index (Chol-/HDL-chol)
could be reduced on an average of 14,3% in relation to the initial va
lue. A good long-term compliance of the patients could-be achieved by
the lack of side effects and its form of administration as a palatable
viscous drink.