ONLINE PHOTOCHEMICAL DERIVATIZATION AND FLOW-INJECTION SPECTROPHOTOMETRIC DETERMINATION OF ERGONOVINE MALEATE

Authors
ROMERO AM BENITO GG CALATAYUD JM
Citation
Am. Romero et al., ONLINE PHOTOCHEMICAL DERIVATIZATION AND FLOW-INJECTION SPECTROPHOTOMETRIC DETERMINATION OF ERGONOVINE MALEATE, Analytica chimica acta, 282(1), 1993, pp. 95-100
Citations number
15
Categorie Soggetti
Chemistry Analytical
Journal title
Analytica chimica acta → ACNP
ISSN journal
00032670
Volume
282
Issue
1
Year of publication
1993
Pages
95 - 100
Database
ISI
SICI code
0003-2670(1993)282:1<95:OPDAFS>2.0.ZU;2-A
Abstract
A flow-injection manifold is proposed for the on-line photochemical de rivatization of ergonovine maleate with application to pharmaceutical formulations. The procedure is based on the reaction with p-dimethylam inobenzaldehyde in presence of iron(III) and sulphuric acid medium. Th e reaction rate is improved by irradiation of the solution with a merc ury lamp (254.0 nm). The calibration graph is linear over the range 3- 74 mug ml-1 ergonovine, with a mid-range R.S.D. of 1.7% and a sample t hroughput of 34 h - 1. The influence of foreign compounds was tested.