The need to reduce economic and environmental costs of livestock agric
ulture has led to a resurgence of interest in forage legumes, particul
arly white clover. However, despite a recognition of the benefits accr
uing from its high herbage quality and the nitrogen fixation from its
symbiosis with the Rhizobium bacterium, the widespread use of white cl
over by farmers has been inhibited by several perceived problems. Fore
most amongst these have been a reputation for unreliable yield, lack o
f persistency under intensive grazing and propensity to cause bloat in
cattle. Conventional breeding techniques coupled with extensive genet
ic resources and a growing understanding of the physiological basis of
variation in yield and persistency have already resulted in the devel
opment of new reliably productive varieties. These varieties will prov
ide a cornerstone for sustainable livestock agriculture in upland and
lowland areas of the UK and Europe. The successful application of tech
niques of biotechnology to white clover has accelerated in recent year
s. An array of approaches is now available which will open the way for
its genetic manipulation and subsequent germplasm enhancement. These
approaches range from the routine maintenance and propagation of plant
s in vitro to the production of transgenic plants, and offer possibili
ties of altering radically the nature of white clover in the future.