PERIPHERAL ANTINOCICEPTIVE EFFECTS OF MORPHINE AFTER BURN INJURY

Authors
MOINICHE S DAHL JB KEHLET H
Citation
S. Moiniche et al., PERIPHERAL ANTINOCICEPTIVE EFFECTS OF MORPHINE AFTER BURN INJURY, Acta anaesthesiologica Scandinavica, 37(7), 1993, pp. 710-712
Citations number
18
Categorie Soggetti
Anesthesiology
Journal title
Acta anaesthesiologica Scandinavica → ACNP
ISSN journal
00015172
Volume
37
Issue
7
Year of publication
1993
Pages
710 - 712
Database
ISI
SICI code
0001-5172(1993)37:7<710:PAEOMA>2.0.ZU;2-A
Abstract
In a double-blind study, 2 mg of morphine in saline, or saline only, w as given subcutaneously into a second-degree bilateral leg-burn injury in 12 volunteers. Heat-pain thresholds and pressure-pain thresholds w ere significantly increased by local morphine administration. These re sults confirm experimental data demonstrating a peripheral antinocicep tive effects of opioids in inflamed tissue.