THE TOPICAL APPLICATION OF VERAPAMIL AND NIFEDIPINE LOWERS INTRAOCULAR-PRESSURE IN CONSCIOUS RABBITS

Authors
SEGARRA J SANTAFE J GARRIDO M DEIBARRETA MJM
Citation
J. Segarra et al., THE TOPICAL APPLICATION OF VERAPAMIL AND NIFEDIPINE LOWERS INTRAOCULAR-PRESSURE IN CONSCIOUS RABBITS, General pharmacology, 24(5), 1993, pp. 1163-1171
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
24
Issue
5
Year of publication
1993
Pages
1163 - 1171
Database
ISI
SICI code
0306-3623(1993)24:5<1163:TTAOVA>2.0.ZU;2-0
Abstract
1. The time-course of the ocular effects of topical verapamil and nife dipine as well as the dose-response relationship, were studied in cons cious, normotensive rabbits. 2. Both drugs caused a dose-dependent fal l of intraocular pressure, which lasted 4 hr or more. 3. Log dose-resp onse curves of both drugs show a similar peak response, but the potenc y of verapamil was greater than that of nifedipine. 4. A fall in the i ntraocular pressure in the untreated eye was also observed. 5. Verapam il and nifedipine induced a reduction of the tonographic outflow facil ity in the treated eye.