EVIDENCE THAT THE RAD1 AND RAD10 PROTEINS OF SACCHAROMYCES-CEREVISIAEPARTICIPATE AS A COMPLEX IN NUCLEOTIDE EXCISION-REPAIR OF UV-RADIATION DAMAGE

A newly characterized rad1 missense mutation (rad1-20) in the yeast Sa ccharomyces cerevisiae maps to a region of the Rad1 polypeptide known to be required for Rad1-Rad10 complex formation. The UV sensitivity of the rad1-20 mutant can be partially and specifically corrected by ove rexpression of wild-type Rad10 protein. These results suggest that com plex formation between the Rad1 and Rad10 proteins is required for nuc leotide excision repair.