2 RARE MANIFESTATIONS OF MELANOMAS - GENERALIZED CUTANEOUS MELANOSIS AND RAPID SOLAR INDUCTION OF SHOWERS OF SMALL PIGMENTED LESIONS - A CRITICAL-REVIEW OF THE LITERATURE AND PRESENTATION OF 2 ADDITIONAL CASES

Two unusual patients with metastatic melanoma are presented. One had g eneralized melanosis, and the other a rapid induction of multiple smal l pigmented lesions within a day of exposure to the sun. From a variet y of clinical observations on these 2 patients and ones reported in th e literature, and from recent advances in basic biomedical knowledge, we conclude that in both conditions the anomalous presence of growth f actors that stimulate the proliferation and melanogenic differentiatio n of normal and malignant melanocytes played a major role in producing the clinical events.