PENBUTOLOL SELECTIVE-MEMBRANE SENSOR

The construction and performance characteristics of ion-selective PVC membrane electrode for penbutolol sulfate are described. The electrode , based on ion-pair complex with dinonyylnaphthalenesulphonate anion, shows near-Nernstian response in the range 10(-3) to 5 x 10(-6) M drug concentration. Its selectivity relative to various cations is reporte d. Potentimetric methods are used to determine pure drug-substance and active principle in pharmaceutical preparation with good results. It was also applied to the determination of content uniformity and dissol ution-rate of film-coated Betapresin(R) tablets.