EFFECTS OF FERRIC CITRATE INJECTION ON THE COMPOSITION OF BILE-ACIDS IN RATS

Authors
NODA Y OGURA M EDAMATSU R ITOH T YUFU K MORI A
Citation
Y. Noda et al., EFFECTS OF FERRIC CITRATE INJECTION ON THE COMPOSITION OF BILE-ACIDS IN RATS, Research communications in chemical pathology and pharmacology, 81(3), 1993, pp. 373-376
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in chemical pathology and pharmacology → ACNP
ISSN journal
00345164
Volume
81
Issue
3
Year of publication
1993
Pages
373 - 376
Database
ISI
SICI code
0034-5164(1993)81:3<373:EOFCIO>2.0.ZU;2-H
Abstract
Ferric citrate was examined for its possible induction of acute and ch ronic changes in bile acids in rats. Three hours after a single intrav enous Fe(III) injection both the biliary bile acid level and the perce ntage of cholic acid in bile were significantly higher in treated rats than in control rats. However, no significant difference was observed after treatment with the same daily dose for one week. The superoxide dismutase (SOD) activity in liver tissue increased in the chronic gro up. These results suggest that oxygen free radicals, mainly the hydrox yl radical, promote hydroxylation during bile acid biosynthesis by enh anced monooxygenase activity.