MATERNAL SERUM SCREENING FOR NEURAL-TUBE DEFECTS AND FETAL CHROMOSOME-ABNORMALITIES

Authors
ROSE NC MENNUTI MT
Citation
Nc. Rose et Mt. Mennuti, MATERNAL SERUM SCREENING FOR NEURAL-TUBE DEFECTS AND FETAL CHROMOSOME-ABNORMALITIES, Western journal of medicine, 159(3), 1993, pp. 312-317
Citations number
35
Categorie Soggetti
Medicine, General & Internal
Journal title
Western journal of medicine → ACNP
ISSN journal
00930415
Volume
159
Issue
3
Year of publication
1993
Pages
312 - 317
Database
ISI
SICI code
0093-0415(1993)159:3<312:MSSFND>2.0.ZU;2-N
Abstract
Second-trimester maternal serum screening is a noninvasive means of id entifying pregnant women at an increased risk for various conditions i ncluding a fetus with open spina bifida, fetal Down syndrome, trisomy 18, multiple gestation, and adverse pregnancy outcome. Combinations of several different markers are available for screening. These include alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estr iol. In this review, we discuss the benefits and limitations of the sc reening tests and the suggested protocols for the care of patients.