U. Hording et al., HUMAN PAPILLOMAVIRUS IN VULVAR SQUAMOUS-CELL CARCINOMA AND IN NORMAL VULVAR TISSUES - A SEARCH FOR A POSSIBLE IMPACT OF HPV ON VULVAR CANCER PROGNOSIS, International journal of cancer, 55(3), 1993, pp. 394-396
Paraffin-embedded sections of vulvar squamous-cell carcinomas and of n
ormal vulvar tissues were examined for HPV types 6, 11, 16, 18 and 33
by the polymerase chain reaction. Overall, 19 of 62 tumours harboured
HPV DNA of types 16, 18 or 33. HPV types 6 and 11 were not detected. H
PV DNA was found in 61% of tumours with adjacent intraepithelial neopl
asia (VIN III), and in 13% of tumours without associated VIN III. HPV
DNA was not detected in any of 101 normal vulvar tissues. HPV DNA was
found more often in younger women, in patients with VIN III-associated
tumours, and in those with multicentric anogenital neoplasia. This po
ints to the existence of a subset of vulvar carcinomas preceded by int
raepithelial neoplasia, with HPV as a major factor in carcinogenesis.
HPV also seems to be an important factor in the development of multipr
imaries in these patients. The 2 groups of patients with vulvar carcin
oma did not differ with regard to prognosis, as estimated by the risk
of recurrence after primary surgery. (C) 1993 Wiley-Liss, Inc.