THE SYNTHESIS OF FLUORINATED 4H-1,4-BENZOTHIAZINE-2-CARBOXYLIC ACID 1,1-DIOXIDES-THIONATED ANALOGS OF PEFLOXACIN

Authors
VYSOKOV VI CHARUSHIN VN AFANASYEVA GB CHUPAKHIN ON
Citation
Vi. Vysokov et al., THE SYNTHESIS OF FLUORINATED 4H-1,4-BENZOTHIAZINE-2-CARBOXYLIC ACID 1,1-DIOXIDES-THIONATED ANALOGS OF PEFLOXACIN, Mendeleev communications, (4), 1993, pp. 159-160
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Mendeleev communications → ACNP
ISSN journal
09599436
Issue
4
Year of publication
1993
Pages
159 - 160
Database
ISI
SICI code
0959-9436(1993):4<159:TSOF4A>2.0.ZU;2-2
Abstract
A synthetic route to 1,4-benzothiazine-2-carboxylic acid 1,1-dioxides, analogues of the 'fluoroquinolone' family of antibacterials, has been developed; unfortunately, the target compound (the thia-analogue of p efloxacin) has not revealed remarkable antibacterial activity in vitro against the majority of the strains tested.