ISOLATION AND IDENTIFICATION OF A NOVEL ISOMERIZED EPOXIDE METABOLITEOF FK-506 FROM ERYTHROMYCIN-INDUCED RABBIT LIVER-MICROSOMES

Authors
LHOEST G MATON N VERBEECK RK
Citation
G. Lhoest et al., ISOLATION AND IDENTIFICATION OF A NOVEL ISOMERIZED EPOXIDE METABOLITEOF FK-506 FROM ERYTHROMYCIN-INDUCED RABBIT LIVER-MICROSOMES, Drug metabolism and disposition, 21(5), 1993, pp. 850-854
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug metabolism and disposition → ACNP
ISSN journal
00909556
Volume
21
Issue
5
Year of publication
1993
Pages
850 - 854
Database
ISI
SICI code
0090-9556(1993)21:5<850:IAIOAN>2.0.ZU;2-1
Abstract
A novel metabolite of FK-506-a C-13, C-15, C31 O-demethyl C19 hydroxym ethyl C36 isomerized epoxide of FK-506 obtained from erythromycin-indu ced rabbit liver microsomes-was isolated by HPLC and identified by FAB /MS and NMR. The existence of ring-chain tautomers for this metabolite is demonstrated by NMR spectroscopy. FAB/MS, and HPLC.