HETEROLOGOUS PERIPHERAL-BLOOD STEM-CELL T RANSPLANTATION IN 2 PATIENTS

The first two cases in Mexico of patients with hematological malignanc ies treated with heterologous peripheral blood stem cell transplantati on are presented. The stem cells were mobilized in the siblings by mea ns of filgrastim; in one case, the graft was obtained from an identica l twin and in the other from an HLA-identical sibling. In both instanc es the post-transplant aplasia lasted less than 15 years and the engra ftment was complete. In the allogeneic transplantation, the graft vers us host disease was treated with immunosuppresion. The approximate cos t of each of these procedures was 20 000 US dollars. The advantages of grafting heterologous peripheral blood stem cells instead of bone mar row cells are briefly discussed, focusing on economic aspects.