BIOCHEMICAL MODIFICATIONS IN THE BLOOD AND THE HEATED FLUIDS DURING INTRAPERITONEAL CHEMOHYPERTHERMIA

The biochemical changes in blood during intraperitoneal chemohyperther mia (IPCH) were examined by carrying out complete assessments before a nd after the operation. These assessments were made up of 23 parameter s: Na, K, Cl, CO2, urea, creatinine, proteins, glucose, calcium, phosp hates, magnesium, bilirubin, uric acid, lactic acid, CRP, ASAT, ALAT, CK, LDH, gamma-GT, ALP, lipase, and amylase. Only 5 of these parameter s showed significant changes: proteins, urea, ALP, gamma-GT, lactic ac id. The protein and urea levels decreased due to hemodilution induced by the perfusion of fluids. ALP and gamma-GT levels decreased, possibl y due to localized inhibition of secretion. Lactic acid levels increas ed due to the movement of lactates from the heated fluid into the bloo d. The study of biochemical changes within the heated fluids was made using the following parameters: CA 125, CA 19-9, CEA, ASAT, ALAT, CK, LDH, gamma-GT, ALP, lipase, uric acid, phosphates, proteins, Na, K, Cl , urea, creatinine, and magnesium. Between the beginning and the end o f IPCH, significant increases were found in the levels of CA 125 (+173 %), proteins (+190%), ASAT (+130%), LDH (+103%), K+ (+232%), PO4 (+134 %), and uric acid (+99%). These increases indicate the existence of a significant degree of cellular lysis.