A synthetic routs has been developed for the preparation of, inter ali
a, a benzo[2,3-c]pyranquinone with a view to making the route more gen
erally applicable to the synthesis of naturally occurring naphtho[2,3-
c]pyranquinones and other quinones of potential importance as bioreduc
tive alkylating agents. The synthetic quinones and their precursors we
re tested in vitro for antimicrobial activity.