APPLICATION OF SODIUM AMALGAM REDUCTIVE ELIMINATION OF ALLYLIC DIBENZOATES TO THE TOTAL SYNTHESIS OF 5(S)-12 (R) LEUKOTRIENE-B(4)

Authors
SOLLADIE G URBANO A STONE GB
Citation
G. Solladie et al., APPLICATION OF SODIUM AMALGAM REDUCTIVE ELIMINATION OF ALLYLIC DIBENZOATES TO THE TOTAL SYNTHESIS OF 5(S)-12 (R) LEUKOTRIENE-B(4), Tetrahedron letters, 34(40), 1993, pp. 6489-6492
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
40
Year of publication
1993
Pages
6489 - 6492
Database
ISI
SICI code
0040-4039(1993)34:40<6489:AOSARE>2.0.ZU;2-Z
Abstract
A stereoselective synthesis of 5(S)-12(R) LTB4 is described in this pa per using a novel reaction, the sodium amalgam induced reductive elimi nation of allylic dibenzoates for the selective synthesis of the E,E,Z - triene moiety. The creation of the chiral centers was controled by a chiral sulfoxide group.