Reactions between lactic acid and alcohols or carboxylic acids catalyz
ed by lipase from Candida antarctica were evaluated with hexane as sol
vent. Lactic acid was a good acyl donor and esters of both primary and
secondary alcohols were effectively synthesized. No interfering dimer
formation due to lactic acid acting as both nucleophile and acyl dono
r was observed. In agreement with this, no esterification occurred bet
ween lactic acid and carboxylic acids.