Purpose: To compare fundus photography with ophthalmoscopy in the dete
ction of diabetic retinopathy. Methods: Ophthalmoscopy and fundus phot
ographs with a nonmydriatic camera, both performed through dilated pup
ils, were compared to diagnose retinopathy in a cohort of 410 Oklahoma
Indians with noninsulin-dependent diabetes mellitus. A total of 795 e
yes were examined using both methods. The mean age of participants was
60.3 years, with a mean duration of diabetes of 17.3 years. Results:
An overall agreement of 86.3% with a kappa statistic K of 0.74 was fou
nd between ophthalmoscopy and fundus photography with a nonmydriatic c
amera. For the diagnosis of proliferative diabetic retinopathy, K = 0.
84 with an agreement of 98.1%. With a total of 61 cases of proliferati
ve retinopathy diagnosed by either method in our study, ophthalmoscopy
alone detected 88.5% and fundus photography, 78.7%. When compared on
a lesion-by-lesion basis, agreement between the two diagnostic methods
was highest for nonproliferative retinopathy, as well as fibrous prol
iferation. Conclusion: The fundus photography with a nonmydriatic came
ra, performed with mydriasis, is comparable to ophthalmoscopy for the
detection of retinopathy. It may prove to be a suitable, cost-effectiv
e method for routine screening in diabetes clinics, provided ophthalmo
logic referral is ensured for those with a diagnosis of any form of re
tinopathy, questionable retinopathy, nondiabetic retinopathy, those wi
th poor quality photographs, as well as those with acute changes in vi
sual acuity .