The design of cardiovascular devices is a complex process that is part
ially, but never completely, illuminated by scientific information and
precise specification of the performance wanted of the device. No des
ign satisfies by only accomplishing its intended goal; it must also av
oid unintended, unwanted effects, termed in this chapter failure modes
. Discussion of these modes is the principal goal of this chapter, whi
ch, however, concludes with a discussion of a feasible process of desi
gn that can be carried out in the presence of substantial ignorance. N
atural components of the cardiovascular system as models for the explo
itation of current technology are suggested to be, at least at present
, less useful than are precedent artificial systems.