Transesophageal echocardiography (TEE) is more sensitive than transtho
racic echocardiography (TTE) in detecting tile potential source of emb
oli in cardioembolic strokes (CES). To establish the prevalence of a p
otential cardiac source of embolism detectable on TEE and its relation
ship to vascular risk factors, an unselected ischemic stroke populatio
n was evaluated. Twenty-six age and sex-matched cases with normal card
iological and neurological examinations as well as normal CT-scans, TT
E and ECGs were included in the study as the control group. One hundre
d and eight patients with cardioembolic stroke (53 patients), atheroth
rombotic stroke (36 patients), and lacunar stroke (19 patients) were i
nvestigated by TTE and TEE. Seven of the 26 (26.9%) controls had thora
cic atherosclerotic plaques on TEE examinations. The prevalence of abn
ormal TEE findings in patients was higher compared to the controls (p
< 0.001). TEE revealed more specific findings in every etiological gro
up when compared to TTE (74.0% vs 10.2%, p < 0.001). Atrial fibrillati
on correlated with the abnormalities of TEE (p < 0.05) while other ris
k factors did not. Left atrial spontaneous echo contrast was the most
common finding on TEE of cases with cardioembolic stroke while atheros
clerotic aortic plaques were mostly encountered in patients with ather
othrombotic stroke. No specific findings by TEE were seen in patients
with lacunar stroke. TEE is capable of detecting definite etiologies i
n cardioembolic stroke and associated cardiac pathologies in atherothr
ombotic stroke and lacunar stroke. These observations suggest that TEE
is a useful tool to guide the physician for the treatment of ischemic
stroke patients.