ASSIGNMENT OF THE DIPEPTIDYLPEPTIDASE-IV (DPP4) GENE TO PIG CHROMOSOME-15Q21

Authors
THOMSEN PD QVIST H MARKLUND L ANDERSSON L SJOSTROM H NOREN O
Citation
Pd. Thomsen et al., ASSIGNMENT OF THE DIPEPTIDYLPEPTIDASE-IV (DPP4) GENE TO PIG CHROMOSOME-15Q21, Mammalian genome, 4(10), 1993, pp. 604-607
Citations number
28
Categorie Soggetti
Biology,"Genetics & Heredity","Biothechnology & Applied Migrobiology
Journal title
Mammalian genome → ACNP
ISSN journal
09388990
Volume
4
Issue
10
Year of publication
1993
Pages
604 - 607
Database
ISI
SICI code
0938-8990(1993)4:10<604:AOTD(G>2.0.ZU;2-E
Abstract
A porcine 2-kb partial dipeptidylpeptidase IV (DPP4, EC 3.4.14.5) cDNA clone and a porcine 16-kb genomic fragment containing parts of the DP P4 gene were isolated, characterized, and used as probes to map the DP P4 gene to pig Chr (Chr) 15q21 by fluorescence in situ hybridization. A two-allele RFLP was revealed for the DPP4 gene. This polymorphism wa s utilized in a linkage test against the erythrocyte antigen G (EAG), previously assigned to Chr 15, and the microsatellite S0088, which is linked to EAG. The linkage analyses revealed significant evidence for linkage confirming the assignment of DPP4 to Chr 15.