CHARACTERIZATION OF THE GENES ENCODING A RECEPTOR-LIKE HISTIDINE KINASE AND A COGNATE RESPONSE REGULATOR FROM A BIPHENYL POLYCHLOROBIPHENYL-DEGRADING BACTERIUM, RHODOCOCCUS SP STRAIN M5/
D. Labbe et al., CHARACTERIZATION OF THE GENES ENCODING A RECEPTOR-LIKE HISTIDINE KINASE AND A COGNATE RESPONSE REGULATOR FROM A BIPHENYL POLYCHLOROBIPHENYL-DEGRADING BACTERIUM, RHODOCOCCUS SP STRAIN M5/, Journal of bacteriology, 179(8), 1997, pp. 2772-2776
We report the cloning, sequence, and expression of the bpdS and bpdT g
enes from Rhodococcus sp. strain MS, which are believed to encode the
first two-component signal transduction system in the genus Rhodococcu
s, which potentially regulates biphenyl/polychlorobiphenyl metabolism
in M5. BpdT has a typical responses regulator sequence (209 amino acid
s; 23 kDa), whereas BpdS, the predicted histidine kinase component, is
an unusually large transmembrane protein (1,576 amino acids; 170 kDa)
that contains ATP-binding and leucinerich repeat motifs and some cons
erved residues of protein kinases. Expression of bpdST, like that of t
he bpdC1C2BADE degradative operon, is inducible by biphenyl.