ASYMMETRIC-SYNTHESIS AND ABSOLUTE STEREOCHEMISTRY OF 4,4-BIS(TRIFLUOROMETHYL)IMIDAZOLINE BASED ACAT INHIBITORS

Authors
LI HY DELUCCA I DRUMMOND S BOSWELL GA
Citation
Hy. Li et al., ASYMMETRIC-SYNTHESIS AND ABSOLUTE STEREOCHEMISTRY OF 4,4-BIS(TRIFLUOROMETHYL)IMIDAZOLINE BASED ACAT INHIBITORS, Tetrahedron, 53(15), 1997, pp. 5359-5372
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
15
Year of publication
1997
Pages
5359 - 5372
Database
ISI
SICI code
0040-4020(1997)53:15<5359:AAASO4>2.0.ZU;2-X
Abstract
An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, i s reported. The absolute configuration of 1 has been determined by exc iton CD spectra and X-ray crystal structure analysis. (C) 1997 The DuP ont Merck Pharmaceutical Company.