SYNTHESIS OF FLUORESCENT-PROBES FOR THE DETECTION OF ABASIC SITES IN DNA

Authors
BOTURYN D BOUDALI A CONSTANT JF DEFRANCQ E LHOMME J
Citation
D. Boturyn et al., SYNTHESIS OF FLUORESCENT-PROBES FOR THE DETECTION OF ABASIC SITES IN DNA, Tetrahedron, 53(15), 1997, pp. 5485-5492
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
15
Year of publication
1997
Pages
5485 - 5492
Database
ISI
SICI code
0040-4020(1997)53:15<5485:SOFFTD>2.0.ZU;2-6
Abstract
The three luminescent molecules 1-3 were prepared as highly sensitive and specific probes for the quantification of a major DNA lesion, the abasic site. These molecules incorporate in their structure the reacti ve oxyamino function linked to the Dansyl or Lissamine-Rhodamine fluor ophores through amido or polyether chains. (C) 1997 Elsevier Science L td.