SYNTHESES VIA VINYL SULFONES .71. APPLICATION OF THE GRUBBS RING-CLOSING METATHESIS FOR THE CONSTRUCTION OF A MACROCYCLIC ANSA-BRIDGE - SYNTHESIS OF THE TRICYCLIC CORE OF ROSEOPHILIN
Sh. Kim et al., SYNTHESES VIA VINYL SULFONES .71. APPLICATION OF THE GRUBBS RING-CLOSING METATHESIS FOR THE CONSTRUCTION OF A MACROCYCLIC ANSA-BRIDGE - SYNTHESIS OF THE TRICYCLIC CORE OF ROSEOPHILIN, Tetrahedron letters, 38(15), 1997, pp. 2601-2604
Metalation/alkylation of the pyrrole-fused 10 pi anion 15 regiospecifi
cally yields the beta-alkylated ketones 16,17, Conversion of 17 to die
ne 24 followed by Grubbs ring-closing metathesis provides 29 which is
transformed to the roseophilin tricyclic core structure 5. (C) 1997 El
sevier Science Ltd.