SMI2-MEDIATED REDUCTIVE ENOLIZATION OF ALPHA-HETERO-SUBSTITUTED KETONES AND ENANTIOSELECTIVE PROTONATION

Authors
NAKAMURA Y TAKEUCHI S OHGO Y YAMAOKA M YOSHIDA A MIKAMI K
Citation
Y. Nakamura et al., SMI2-MEDIATED REDUCTIVE ENOLIZATION OF ALPHA-HETERO-SUBSTITUTED KETONES AND ENANTIOSELECTIVE PROTONATION, Tetrahedron letters, 38(15), 1997, pp. 2709-2712
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
15
Year of publication
1997
Pages
2709 - 2712
Database
ISI
SICI code
0040-4039(1997)38:15<2709:SREOAK>2.0.ZU;2-L
Abstract
High enantioselectivity (up to 94% ee) has been achieved in the proton ation of samarium enolates which were generated by SmI2-mediated reduc tion of 2-aryl-2-methoxycyclohexanones using a C-2-symmetric chiral di ol as a proton source. (C) 1997 Elsevier Science Ltd.