SELECTIVE MICROBIAL HYDROXYLATION AND BIOLOGICAL REARRANGEMENT OF TAXOIDS

Authors
HU SH SUN DA TIAN XF FANG QC
Citation
Sh. Hu et al., SELECTIVE MICROBIAL HYDROXYLATION AND BIOLOGICAL REARRANGEMENT OF TAXOIDS, Tetrahedron letters, 38(15), 1997, pp. 2721-2724
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
15
Year of publication
1997
Pages
2721 - 2724
Database
ISI
SICI code
0040-4039(1997)38:15<2721:SMHABR>2.0.ZU;2-I
Abstract
5 alpha,7 beta,9 alpha,10 beta, 13 alpha-Pentaacetoxy-4(20),11-taxadie ne 1 was selectively transformed into its 1 beta,14 beta-hydroxylated derivatives 2, 3, and 11(15-->1)abeotaxane 4 by different filamentous fungi. Microbial transformation of a series of taxoids with a 4(20) ex ocyclic double bond was described. The microbial enzymatic systems may be served as a useful tool to mimic some steps of taxoid biosynthesis in Taxus spp.. (C) 1997 Elsevier Science Ltd.