SYNTHESIS OF ENANTIOMERICALLY PURE DESMETHYL C,D-RING DERIVATIVE OF PACLITAXEL (TAXOL(TM)) VIA ASYMMETRIC DIELS-ALDER REACTION OF 2-SILOXYFURAN

Authors
SHA CK LEE SJ TSENG WH
Citation
Ck. Sha et al., SYNTHESIS OF ENANTIOMERICALLY PURE DESMETHYL C,D-RING DERIVATIVE OF PACLITAXEL (TAXOL(TM)) VIA ASYMMETRIC DIELS-ALDER REACTION OF 2-SILOXYFURAN, Tetrahedron letters, 38(15), 1997, pp. 2725-2728
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
15
Year of publication
1997
Pages
2725 - 2728
Database
ISI
SICI code
0040-4039(1997)38:15<2725:SOEPDC>2.0.ZU;2-9
Abstract
Cycloadduct 3 of the asymmetric Diels-Alder reaction of 2-siloxyfuran 2 and dimethyl acetylenedicarboxylate was converted into the enantiome rically pure desmethyl C,D-ring derivative 13 of Paclitaxel. (C) 1997 Elsevier Science Ltd.